Jeroen de Baaij – Kidney Physiology

News

ZonMW Open Grant to study mitochondrial tubulopathies

Great news from ZonMW, our Open Competition project got funded! The exciting collaboration with Marianne Verhaar and Martijn Koppens can now really take off! In the REPAIR project, we aim…

Citrate modulates calciprotein particle formation and composition

29 Jan 202630 Apr 2026

de La Roij G, van der Meijden RHM, Rutten L, Hoogstraten CA, Hinnen M, Martens S, Hoenderop JGJ, de Baaij JHF. Citrate modulates calciprotein particle formation and composition. Am J…

News

PhD Degree for Anastasia Adella

20 Oct 202530 Apr 2026

Anastasia Adella successfully defended her thesis entitled ‘Beating ADKH-RRAGD: The role of the mTORC1 signaling pathway, and therapeutic perspectives'. Outline of this thesisThis thesis aimed to unravel the molecular mechanisms contributing…

News

PhD Degree for Willem Bosman

29 Sep 202530 Apr 2026

Willem Bosman successfully defended his thesis entitled ‘Many Meetings: Traditional and Novel Players in Magnesium Reabsorption'. Outline of this thesisAlthough the identification of various genetic causes of hypomagnesemia has led to…

News

Pieter Leermakers receives Off Road grant

4 Aug 202530 Apr 2026

Pieter Leermakers will receive an Off Road grant to explore an out-of-the-box ideas within the field of (bio)medical science and healthcare. The Off Road programme challenges creative and adventurous researchers…

Novel RRAGD Variants in Autosomal Dominant Kidney Hypomagnesemia and Therapeutic Perspectives

29 Jul 202530 Apr 2026

Adella A, Jouret F, Madariaga L, Leermakers PA, Arango P, Ariceta G, Beck BB, Bjerre A, Bockenhauer D, Coccia P, Dhamija R, de Frutos F, Garcia-Castano A, van Katwijk SB,…

Calciprotein particle-activated endothelial cells aggravate smooth muscle cell calcification via paracrine signalling

26 Apr 202530 Apr 2026

Feenstra L, Zeper LW, van de Langenberg B, Kahlman EJEM, de La Roij G, Reijrink M, Bernay B, Chatre L, Kuipers J, Giepmans BNG, Mastik MF, Kooistra W, Lodewijk ME,…

Proteomic analysis of urinary extracellular vesicles from patients with ADTKD-HNF1β identifies roles for cilia-related proteins and serpins

1 Apr 202530 Apr 2026

Kahlman EJEM, van Heugten MH, Tholen LE, Verploegen MFA, Spruijt CG, Jansen PWTC, Vermeulen M, Hoenderop JGJ, Hoorn EJ, Nijenhuis T, de Baaij JHF. Proteomic analysis of urinary extracellular vesicles…

A distal convoluted tubule-specific isoform of murine SLC41A3 extrudes magnesium

11 Feb 202530 Apr 2026

Franken GAC, Bosman W, Jung HJ, Bos C, Latta F, Knepper M, Hoenderop JGJ, de Baaij JHF. A distal convoluted tubule-specific isoform of murine SLC41A3 extrudes magnesium. Acta Physiol (Oxf).…

News

PhD Degree for Heidi Schigt

23 Jan 202530 Apr 2026

Heidi Schigt successfully defended her thesis entitled ‘Cut out for the job: how FAM111A regulates STAT1 and magnesium homeostasis'. Outline of this thesisBecause KCS2 is a very rare disorder, KCS2 case…

RRAGD variants cause cardiac dysfunction in a zebrafish model

27 Sep 202430 Apr 2026

Adella A, Tengku F, Arjona FJ, Broekman S, de Vrieze E, van Wijk E, Hoenderop JGJ, de Baaij JHF. RRAGD variants cause cardiac dysfunction in a zebrafish model. Am J Physiol Heart…

Characterization of intestine-specific TRPM6 knockout C57BL/6 J mice: effects of short-term omeprazole treatment

13 Sep 202418 Sep 2024

Adella A, Gommers LMM, Bos C, Leermakers PA, de Baaij JHF, Hoenderop JGJ. Characterization of intestine-specific TRPM6 knockout C57BL/6 J mice: effects of short-term omeprazole treatment. Pflugers Arch. 2024 Sep 13.…

Genetic drivers of age-related changes in urinary magnesium excretion

Abstract Although age-dependent alterations in urinary magnesium (Mg2+) excretion have been described, the underlying mechanism remains elusive. As heritability significantly contributes to variations in urinary Mg2+excretion, we measured urinary Mg2+…

Pathogenic heterozygous TRPM7 variants and hypomagnesemia with developmental delay

6 Jul 20249 Jul 2024

Abstract Background: Heterozygous variants in TRPM7, encoding an essential and ubiquitously expressed cation channel, may cause hypomagnesemia, but current evidence is insufficient to draw definite conclusions and it is unclear whether…

Magnesium Biology

13 Jun 202418 Sep 2024

Kröse JL, de Baaij JHF. Magnesium Biology. Nephrol Dial Transplant. 2024 Jun 13:gfae134. d Abstract Magnesium (Mg2+) is essential for energy metabolism, muscle contraction, and neurotransmission. As part of the…