Publication highlights

Magnesium in Health & Disease

Our mission is to decipher the pathophysiological mechanisms of magnesium disorders. By identification of genes involved in hereditary hypomagnesemia, we aim to increase our understanding of the molecular mechanisms of magnesium reabsorption in the kidney. Embedded in the department of Medical BioSceinces of Radboudumc, we study the regulation of magnesium…Continue reading “Magnesium in Health & Disease”

6Jun 20249 Jul 2024

Magnesium disorders

Touyz RM, de Baaij JHF, Hoenderop JGJ N Engl J Med. 2024 Jun 6;390(21):1998-2009. Abstract Although the past several years have…

5Oct 20239 Jul 2024

Electrolyte Disorders in Mitochondrial Cytopathies: A Systematic Review

Viering DHHM, Vermeltfoort L, Bindels RJM, Deinum J, de Baaij JHF. J Am Soc Nephrol. 2023 Nov 1;34(11):1875-1888. Abstract Background: Electrolyte reabsorption…

27Oct 20229 Jan 2023

Long-Read Sequencing Identifies Novel Pathogenic Intronic Variants in Gitelman Syndrome

Background – Gitelman syndrome is a salt-losing tubulopathy characterized by hypokalemic alkalosis and hypomagnesemia. It is caused by homozygous recessive or compound…

Characterization of intestine-specific TRPM6 knockout C57BL/6 J mice: effects of short-term omeprazole treatment

13 Sep 202418 Sep 2024

Adella A, Gommers LMM, Bos C, Leermakers PA, de Baaij JHF, Hoenderop JGJ. Characterization of intestine-specific TRPM6 knockout C57BL/6 J mice: effects of short-term omeprazole treatment. Pflugers Arch. 2024 Sep 13.…

Genetic drivers of age-related changes in urinary magnesium excretion

Abstract Although age-dependent alterations in urinary magnesium (Mg2+) excretion have been described, the underlying mechanism remains elusive. As heritability significantly contributes to variations in urinary Mg2+excretion, we measured urinary Mg2+…

Pathogenic heterozygous TRPM7 variants and hypomagnesemia with developmental delay

6 Jul 20249 Jul 2024

Abstract Background: Heterozygous variants in TRPM7, encoding an essential and ubiquitously expressed cation channel, may cause hypomagnesemia, but current evidence is insufficient to draw definite conclusions and it is unclear whether…

Magnesium Biology

13 Jun 202418 Sep 2024

Kröse JL, de Baaij JHF. Magnesium Biology. Nephrol Dial Transplant. 2024 Jun 13:gfae134. d Abstract Magnesium (Mg2+) is essential for energy metabolism, muscle contraction, and neurotransmission. As part of the…

Magnesium disorders

6 Jun 20249 Jul 2024

Touyz RM, de Baaij JHF, Hoenderop JGJ N Engl J Med. 2024 Jun 6;390(21):1998-2009. Abstract Although the past several years have seen substantial advances in the understanding of molecular and cellular…

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Rosanna Gusmano ERA Award for Young Investigators in basic science for Jeroen de Baaij

23 May 20249 Jul 2024

Jeroen de Baaij has been awarded the Rosanna Gusmano Young Investigator Award for Basic Science of the European Renal Association (ERA). He receives this prestigious award for his work on the discovery of genetic causes…

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Reducing side effects of proton pump inhibitors

26 Apr 20249 Jul 2024

The Radboudumc Academic Medical Network invests in regional collaboration in the areas of prostate cancer, side effects of proton pump inhibitors, vaccines for individuals with compromised immune systems, and treatment…

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Kolff+ grant for more insight into cardiovascular disease in kidney patients

8 Apr 20249 Jul 2024

The leading cause of death in people with kidney damage is cardiovascular disease. This is probably due to accumulating calcium phosphate crystals in the blood. With a Kolff+ grant from…

Liver and spleen predominantly mediate calciprotein particle clearance in a rat model of chronic kidney disease

3 Apr 20249 Jul 2024

Zeper LW, Bos C, Leermakers PA, Franssen GM, Raavé R, Hoenderop JGJ, de Baaij JHF Am J Physiol Renal Physiol. 2024 Apr 1;326(4):F622-F634 Abstract Calciprotein particles (CPPs) provide an efficient mineral…

Hypomagnesaemia with varying degrees of extrarenal symptoms as a consequence of heterozygous CNNM2 variants

22 Mar 20249 Jul 2024

Bosman W, Franken GAC, de Las Heras J, Madariaga L, Barakat TS, Oostenbrink R, van Slegtenhorst M, Perdomo-Ramírez A, Claverie-Martín F, van Eerde AM, Vargas-Poussou R, Dubourg LD, González-Recio I,…

Magnesium Supplementation Modulates T-cell Function in People with Type 2 Diabetes and Low Serum Magnesium Levels

27 Feb 20249 Jul 2024

Drenthen LCA, Ajie M, de Baaij JHF, Tack CJ, de Galan BE, Stienstra R. J Clin Endocrinol Metab. 2024 Feb 27:dgae097 Abstract Context: Low magnesium levels, which are common in people with…

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PhD Degree for Barnabas Ilenwabor

16 Feb 20249 Jul 2024

Barnabas Ilenwabor successfully defended his thesis entitled ‘Exploring novel regulatory pathways in renal magnesium homeostasis'. Outline of this thesisThe aim of this thesis is to provide further identify and characterize the…

Mitochondrial Dysfunction in Kidney Tubulopathies

12 Feb 20249 Jul 2024

Hoogstraten CA, Hoenderop JG, de Baaij JHF Annu Rev Physiol. 2024 Feb 12;86:379-403 Abstract Mitochondria play a key role in kidney physiology and pathology. They produce ATP to fuel energy-demanding water…

Genome-wide association study of serum magnesium in type 2 diabetes

22 Jan 20249 Jul 2024

Oost LJ, Slieker RC, Blom MT, 't Hart LM, Hoenderop JGJ, Beulens JWJ, de Baaij JHF. Genes Nutr. 2024 Jan 26;19(1):2. Abstract People with type 2 diabetes have a tenfold higher…

Five Questions about Magnesium

16 Nov 20239 Jul 2024

Influencers online are raving about the alleged effects of magnesium. They claim it makes you burst with energy and helps with various ailments, such as fatigue and brain fog. But…