Publications Citrate modulates calciprotein particle formation and composition 29 Jan 202630 Apr 2026 de La Roij G, van der Meijden RHM, Rutten L, Hoogstraten CA, Hinnen M, Martens S, Hoenderop JGJ, de Baaij JHF. Citrate modulates calciprotein particle formation and composition. Am J…
Publications Novel RRAGD Variants in Autosomal Dominant Kidney Hypomagnesemia and Therapeutic Perspectives 29 Jul 202530 Apr 2026 Adella A, Jouret F, Madariaga L, Leermakers PA, Arango P, Ariceta G, Beck BB, Bjerre A, Bockenhauer D, Coccia P, Dhamija R, de Frutos F, Garcia-Castano A, van Katwijk SB,…
Publications Calciprotein particle-activated endothelial cells aggravate smooth muscle cell calcification via paracrine signalling 26 Apr 202530 Apr 2026 Feenstra L, Zeper LW, van de Langenberg B, Kahlman EJEM, de La Roij G, Reijrink M, Bernay B, Chatre L, Kuipers J, Giepmans BNG, Mastik MF, Kooistra W, Lodewijk ME,…
Publications Proteomic analysis of urinary extracellular vesicles from patients with ADTKD-HNF1β identifies roles for cilia-related proteins and serpins 1 Apr 202530 Apr 2026 Kahlman EJEM, van Heugten MH, Tholen LE, Verploegen MFA, Spruijt CG, Jansen PWTC, Vermeulen M, Hoenderop JGJ, Hoorn EJ, Nijenhuis T, de Baaij JHF. Proteomic analysis of urinary extracellular vesicles…
Publications A distal convoluted tubule-specific isoform of murine SLC41A3 extrudes magnesium 11 Feb 202530 Apr 2026 Franken GAC, Bosman W, Jung HJ, Bos C, Latta F, Knepper M, Hoenderop JGJ, de Baaij JHF. A distal convoluted tubule-specific isoform of murine SLC41A3 extrudes magnesium. Acta Physiol (Oxf).…
Publications RRAGD variants cause cardiac dysfunction in a zebrafish model 27 Sep 202430 Apr 2026 Adella A, Tengku F, Arjona FJ, Broekman S, de Vrieze E, van Wijk E, Hoenderop JGJ, de Baaij JHF. RRAGD variants cause cardiac dysfunction in a zebrafish model. Am J Physiol Heart…
Publications Characterization of intestine-specific TRPM6 knockout C57BL/6 J mice: effects of short-term omeprazole treatment 13 Sep 202418 Sep 2024 Adella A, Gommers LMM, Bos C, Leermakers PA, de Baaij JHF, Hoenderop JGJ. Characterization of intestine-specific TRPM6 knockout C57BL/6Â J mice: effects of short-term omeprazole treatment. Pflugers Arch. 2024 Sep 13.…
Publications Genetic drivers of age-related changes in urinary magnesium excretion 24 Jul 2024 Abstract Although age-dependent alterations in urinary magnesium (Mg2+) excretion have been described, the underlying mechanism remains elusive. As heritability significantly contributes to variations in urinary Mg2+excretion, we measured urinary Mg2+…
Publications Pathogenic heterozygous TRPM7 variants and hypomagnesemia with developmental delay 6 Jul 20249 Jul 2024 Abstract Background: Heterozygous variants in TRPM7, encoding an essential and ubiquitously expressed cation channel, may cause hypomagnesemia, but current evidence is insufficient to draw definite conclusions and it is unclear whether…
Publications Magnesium Biology 13 Jun 202418 Sep 2024 Kröse JL, de Baaij JHF. Magnesium Biology. Nephrol Dial Transplant. 2024 Jun 13:gfae134. d Abstract Magnesium (Mg2+) is essential for energy metabolism, muscle contraction, and neurotransmission. As part of the…
Publications Magnesium disorders 6 Jun 20249 Jul 2024 Touyz RM, de Baaij JHF, Hoenderop JGJ N Engl J Med. 2024 Jun 6;390(21):1998-2009. Abstract Although the past several years have seen substantial advances in the understanding of molecular and cellular…
Publications Liver and spleen predominantly mediate calciprotein particle clearance in a rat model of chronic kidney disease 3 Apr 20249 Jul 2024 Zeper LW, Bos C, Leermakers PA, Franssen GM, RaavĂ© R, Hoenderop JGJ, de Baaij JHF Am J Physiol Renal Physiol. 2024 Apr 1;326(4):F622-F634 Abstract Calciprotein particles (CPPs) provide an efficient mineral…
Publications Hypomagnesaemia with varying degrees of extrarenal symptoms as a consequence of heterozygous CNNM2 variants 22 Mar 20249 Jul 2024 Bosman W, Franken GAC, de Las Heras J, Madariaga L, Barakat TS, Oostenbrink R, van Slegtenhorst M, Perdomo-RamĂrez A, Claverie-MartĂn F, van Eerde AM, Vargas-Poussou R, Dubourg LD, González-Recio I,…
Publications Magnesium Supplementation Modulates T-cell Function in People with Type 2 Diabetes and Low Serum Magnesium Levels 27 Feb 20249 Jul 2024 Drenthen LCA, Ajie M, de Baaij JHF, Tack CJ, de Galan BE, Stienstra R. J Clin Endocrinol Metab. 2024 Feb 27:dgae097 Abstract Context: Low magnesium levels, which are common in people with…
Publications Mitochondrial Dysfunction in Kidney Tubulopathies 12 Feb 20249 Jul 2024 Hoogstraten CA, Hoenderop JG, de Baaij JHF Annu Rev Physiol. 2024 Feb 12;86:379-403 Abstract Mitochondria play a key role in kidney physiology and pathology. They produce ATP to fuel energy-demanding water…
Kidney Physiology 