Jeroen de Baaij – Page 2 – Kidney Physiology

Oral magnesium supplementation does not affect insulin sensitivity in people with insulin-treated type 2 diabetes and a low serum magnesium: a randomised controlled trial

3 Nov 20239 Jul 2024

Drenthen LCA, de Baaij JHF, Rodwell L, van Herwaarden AE, Tack CJ, de Galan BE. Diabetologia. 2024 Jan;67(1):52-61 Abstract Aims/hypothesis: Hypomagnesaemia has been associated with insulin resistance and an increased risk of…

Cleft palate and minor metabolic disturbances in a mouse global Arl15 gene knockout

1 Nov 20239 Jul 2024

Bai Y, Bentley L, Ma C, Naveenan N, Cleak J, Wu Y, Simon MM, Westerberg H, Cañas RC, Horner N, Pandey R, Paphiti K, Schulze U, Mianné J, Hough T,…

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Best Publication of 2022 Award

13 Oct 20239 Jul 2024

The Dutch Federation of Nephrology selected our paper on the identification of mtDNA mutations as cause of Gitelman syndroom as the Best Publication of 2022! Read more

Electrolyte Disorders in Mitochondrial Cytopathies: A Systematic Review

5 Oct 20239 Jul 2024

Viering DHHM, Vermeltfoort L, Bindels RJM, Deinum J, de Baaij JHF. J Am Soc Nephrol. 2023 Nov 1;34(11):1875-1888. Abstract Background: Electrolyte reabsorption in the kidney has a high energy demand. Proximal and…

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PhD Degree for Lara Zeper

31 Aug 20235 Oct 2023

Lara Zeper successfully defended her thesis entitled ‘Clearing up calciprotein particles in chronic kidney disease'. Outline of this thesisChronic kidney disease (CKD) is associated with cardiovascular events and mortality. Vascular calcification…

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PhD Degree for Lynette Oost

12 Apr 20235 Oct 2023

Lynette Oost successfully defended her thesis entitled ‘Magnesium at the Heart of Insulin Signaling in Diabetes Mellitus’. Outline of this thesisA low serum magnesium level (hypomagnesemia) is often seen in people with…

Expanding the Phenotypic Spectrum of Kenny-Caffey Syndrome

14 Mar 20239 Jul 2024

Schigt H, Bald M, van der Eerden BCJ, Gal L, Ilenwabor BP, Konrad M, Levine MA, Li D, Mache CJ, Mackin S, Perry C, Rios FJ, Schlingmann KP, Storey B,…

Magnesium reabsorption in the kidney

17 Feb 20239 Jul 2024

de Baaij JHF Am J Physiol Renal Physiol. 2023 Mar 1;324(3):F227-F244. Abstract Mg2+ is essential for many cellular and physiological processes, including muscle contraction, neuronal activity, and metabolism. Consequently, the blood…

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PhD Degree for Lotte Tholen

25 Jan 20235 Oct 2023

Lotte Tholen successfully defended her thesis entitled ‘Capturing HNF1β-mediated gene expression in the kidney’. Outline of this thesisHepatocyte nuclear factor 1β (HNF1β) is a transcription factor involved in the development and homeostasis…

Gitelman Syndrome

Gitelman syndrome was described originally in 1966 by dr. Hillel Gitelman as a syndrome of hypokalemia and hypomagnesemia, it was associated with metabolic alkalosis and RAAS activation:https://t.co/No8k7WkRxS The symptoms of…

Transcription factor HNF1β controls a transcriptional network regulating kidney cell structure and tight junction integrity

22 Dec 20229 Jan 2023

Mutations in the HNF1B gene cause autosomal dominant tubulointerstitial kidney disease (ADTKD)-HNF1β, a rare and heterogenous disease characterized by renal cysts and/or malformation, maturity-onset diabetes of the young, hypomagnesemia and…

HNF1β-associated cyst development and electrolyte disturbances are not explained by BAIAP2L2 expression

15 Dec 202210 Jan 2023

Mutations or deletions in transcription factor hepatocyte nuclear factor 1 homeobox β (HNF1β) cause renal cysts and/or malformation, maturity-onset diabetes of the young and electrolyte disturbances. Here, we applied a…

Hypomagnesemia and Cardiovascular Risk in Type 2 Diabetes

8 Nov 20229 Jan 2023

Hypomagnesemia is tenfold more common in individuals with type 2 diabetes (T2D), compared to the healthy population. Factors that are involved in this high prevalence are low Mg2+ intake, gut…

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Magnesium session @ ASN Kidney Week

5 Nov 20229 Jan 2023

Hope to meet you all at the magnesium session: Saturday 2PM at room W414!

Calciprotein Particle Synthesis Strategy Determines In Vitro Calcification Potential

4 Nov 202210 Jan 2023

Circulating calciprotein particles (CPP), colloids of calcium, phosphate and proteins, were identified as potential drivers of the calcification process in chronic kidney disease. The present study compared CPP produced using…