Publications Characterization of intestine-specific TRPM6 knockout C57BL/6 J mice: effects of short-term omeprazole treatment 13 Sep 202418 Sep 2024 Adella A, Gommers LMM, Bos C, Leermakers PA, de Baaij JHF, Hoenderop JGJ. Characterization of intestine-specific TRPM6 knockout C57BL/6 J mice: effects of short-term omeprazole treatment. Pflugers Arch. 2024 Sep 13.…
Publications Genetic drivers of age-related changes in urinary magnesium excretion 24 Jul 2024 Abstract Although age-dependent alterations in urinary magnesium (Mg2+) excretion have been described, the underlying mechanism remains elusive. As heritability significantly contributes to variations in urinary Mg2+excretion, we measured urinary Mg2+…
Publications Pathogenic heterozygous TRPM7 variants and hypomagnesemia with developmental delay 6 Jul 20249 Jul 2024 Abstract Background: Heterozygous variants in TRPM7, encoding an essential and ubiquitously expressed cation channel, may cause hypomagnesemia, but current evidence is insufficient to draw definite conclusions and it is unclear whether…
Publications Magnesium Biology 13 Jun 202418 Sep 2024 Kröse JL, de Baaij JHF. Magnesium Biology. Nephrol Dial Transplant. 2024 Jun 13:gfae134. d Abstract Magnesium (Mg2+) is essential for energy metabolism, muscle contraction, and neurotransmission. As part of the…
Publications Magnesium disorders 6 Jun 20249 Jul 2024 Touyz RM, de Baaij JHF, Hoenderop JGJ N Engl J Med. 2024 Jun 6;390(21):1998-2009. Abstract Although the past several years have seen substantial advances in the understanding of molecular and cellular…
Publications Liver and spleen predominantly mediate calciprotein particle clearance in a rat model of chronic kidney disease 3 Apr 20249 Jul 2024 Zeper LW, Bos C, Leermakers PA, Franssen GM, Raavé R, Hoenderop JGJ, de Baaij JHF Am J Physiol Renal Physiol. 2024 Apr 1;326(4):F622-F634 Abstract Calciprotein particles (CPPs) provide an efficient mineral…
Publications Hypomagnesaemia with varying degrees of extrarenal symptoms as a consequence of heterozygous CNNM2 variants 22 Mar 20249 Jul 2024 Bosman W, Franken GAC, de Las Heras J, Madariaga L, Barakat TS, Oostenbrink R, van Slegtenhorst M, Perdomo-Ramírez A, Claverie-Martín F, van Eerde AM, Vargas-Poussou R, Dubourg LD, González-Recio I,…
Publications Magnesium Supplementation Modulates T-cell Function in People with Type 2 Diabetes and Low Serum Magnesium Levels 27 Feb 20249 Jul 2024 Drenthen LCA, Ajie M, de Baaij JHF, Tack CJ, de Galan BE, Stienstra R. J Clin Endocrinol Metab. 2024 Feb 27:dgae097 Abstract Context: Low magnesium levels, which are common in people with…
Publications Mitochondrial Dysfunction in Kidney Tubulopathies 12 Feb 20249 Jul 2024 Hoogstraten CA, Hoenderop JG, de Baaij JHF Annu Rev Physiol. 2024 Feb 12;86:379-403 Abstract Mitochondria play a key role in kidney physiology and pathology. They produce ATP to fuel energy-demanding water…
Publications Genome-wide association study of serum magnesium in type 2 diabetes 22 Jan 20249 Jul 2024 Oost LJ, Slieker RC, Blom MT, 't Hart LM, Hoenderop JGJ, Beulens JWJ, de Baaij JHF. Genes Nutr. 2024 Jan 26;19(1):2. Abstract People with type 2 diabetes have a tenfold higher…
Publications Oral magnesium supplementation does not affect insulin sensitivity in people with insulin-treated type 2 diabetes and a low serum magnesium: a randomised controlled trial 3 Nov 20239 Jul 2024 Drenthen LCA, de Baaij JHF, Rodwell L, van Herwaarden AE, Tack CJ, de Galan BE. Diabetologia. 2024 Jan;67(1):52-61 Abstract Aims/hypothesis: Hypomagnesaemia has been associated with insulin resistance and an increased risk of…
Publications Cleft palate and minor metabolic disturbances in a mouse global Arl15 gene knockout 1 Nov 20239 Jul 2024 Bai Y, Bentley L, Ma C, Naveenan N, Cleak J, Wu Y, Simon MM, Westerberg H, Cañas RC, Horner N, Pandey R, Paphiti K, Schulze U, Mianné J, Hough T,…
Publications Electrolyte Disorders in Mitochondrial Cytopathies: A Systematic Review 5 Oct 20239 Jul 2024 Viering DHHM, Vermeltfoort L, Bindels RJM, Deinum J, de Baaij JHF. J Am Soc Nephrol. 2023 Nov 1;34(11):1875-1888. Abstract Background: Electrolyte reabsorption in the kidney has a high energy demand. Proximal and…
Publications Expanding the Phenotypic Spectrum of Kenny-Caffey Syndrome 14 Mar 20239 Jul 2024 Schigt H, Bald M, van der Eerden BCJ, Gal L, Ilenwabor BP, Konrad M, Levine MA, Li D, Mache CJ, Mackin S, Perry C, Rios FJ, Schlingmann KP, Storey B,…
Publications Magnesium reabsorption in the kidney 17 Feb 20239 Jul 2024 de Baaij JHF Am J Physiol Renal Physiol. 2023 Mar 1;324(3):F227-F244. Abstract Mg2+ is essential for many cellular and physiological processes, including muscle contraction, neuronal activity, and metabolism. Consequently, the blood…
Kidney Physiology 